The Indianapolis Colts are taking no chances with Andrew Luck — or Adam Vinatieri.

Coach Frank Reich said Friday that he expects Luck, his starting quarterback, to miss at least three more practices with a strained left calf. That would keep him off the field until Wednesday, when the Cleveland Browns come to town for a joint practice.

“He is continuing to progress with his strength, which is awesome,” Reich said on a conference call. “But there still is a degree of pain that he is not comfortable with. Obviously, we are not comfortable with putting him out there.”

The injury kept Luck out of the Colts’ offseason workouts and he was sidelined again after practicing three times over the first four days of training camp, though he didn’t take a snap in full team drills.

Backup Jacoby Brissett has worked with the starting offense. Brissett played most of the first quarter in Thursday’s 24-16 loss at Buffalo before turning things over to Phillip Walker and Chad Kelly, the nephew of former Bills star Jim Kelly.

Reich declined to say whether Luck’s injury might prompt the Colts to activate three quarterbacks for the Sept. 8 season opener against the Los Angeles Chargers.

“We remain confident and optimistic on Andrew’s situation,” Reich said. “But again, it’s still day-to-day and working through that plan, what is the best plan for him, for the team. So we will just adjust as needed, if needed.”

Luck led the Colts to the playoffs for the first time in four years last season and won the NFL’s Comeback Player of the Year award after returning from shoulder surgery that caused him to miss the 2017 season.

The Colts also acknowledged Friday that Vinatieri was held out of Thursday’s game because of a knee injury. The 46-year-old, four-time Super Bowl champion broke the league’s career scoring record last season and would become the third player in league history to suit up for a game at age 47 if he plays in Indy’s regular-season finale at Jacksonville.

Browns’ Callaway suspended: The NFL suspended Browns wide reciever Antonio Callaway for four games without pay for an unspecified violation of the league’s policy and program on substance abuse. Callaway will sit out the first four regular-season games.

“I take full responsibility for my actions,” Callaway said in a news release provided by the Browns. “I made a mistake and I own that. I have taken steps to make myself better and I appreciate the Browns standing by me and supporting me during this time. I know there’s nothing I can say to regain trust; it will all be about my actions.”

Briefly: The Eagles acquired defensive end Eli Harold in a trade that sent rookie offensive lineman Ryan Bates to the Bills. Harold has nine sacks in 61 career games, including 24 starts. ... The Broncos placed tight end Austin Fort, who tore his ACL in a 22-14 preseason loss to the Seahawks on Thursday, on injured reserve and signed offensive lineman Adam Bisnowaty.